Structure of PDB 6ica Chain B Binding Site BS01

Receptor Information

>6ica Chain B (length=371) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPVHEQLQVPQCLAAKITVPHKILAENKEFKIIDVLSSDVETLTILADKV
SCGHFVNVSHKLQQQSAQKLLQKKLVKPFGVSKLHKDVYEIKHEEEVNAA
LKEIVSDNIWQTLTHMTSYYNRSATKDTGVDTANWLKSKFEQMAVEYGRT
DTSTFFVKTGWYKQPSLVTVIGKDIKAPAIVIGAHMDTLDGRMPGAGDDG
SGSSSIMEAARVILSSKTTFKRPIYFIWYAAEERGLVGSQHVVQHFQEQS
IPVKAVVQFDMTGYRNDANDPTMWVFTDYTDRDLSNYLAKLIDHYIHVPV
DYSRCGYGCSDHASWNEEDIPAAFPCETSFADHNPYIHTSSDKMDLLNLE
HMTNFSKLAVAFAIELASELE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6ica Chain B Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6ica The crystal structure of Legionella pneumophila LapA aminopeptidase
Resolution	2.195 Å
Binding residue (original residue number in PDB)	H238 D251 D313
Binding residue (residue number reindexed from 1)	H185 D198 D260
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H238 D251 E285 E286 D313 H391
Catalytic site (residue number reindexed from 1)	H185 D198 E232 E233 D260 H338
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0004177	aminopeptidase activity
GO:0008235	metalloexopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

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Biological Process

External links

PDB	RCSB:6ica, PDBe:6ica, PDBj:6ica
PDBsum	6ica
PubMed
UniProt	Q5ZRR6

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