Structure of PDB 6hzf Chain B Binding Site BS01

Receptor Information
>6hzf Chain B (length=848) Species: 732242 (Phocaeicola paurosaccharolyticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNVVMTGDMTTRLAFAGEQLKQALVEKGYEVNKRSIYLNLLNKNKERFDI
STKGKNTYVTGYDGNGIIYGCRELIDQLDQSGTMDFKPVSDAPEMVLRGA
CIGLQKTTYLPGHAVYEYPYTPESFPWFYDKERWIKYLDMMVENRMNSLY
LWNGHPFASLVKLKDYPFALEVDEETFKKNEEMFSFLTTEAEKRGIFVIQ
MFYNIIVSKPFADHYGIKTQDRNRPITPLISDYTRKSVAAFIEKYPNVGL
LVCLGEAIGTYEEDVEWFTKTIIPGIKDGLKVLGRTDEPPVLVRAHDTDC
KMVIDAALPLYKNLYTMHKYNGESLTTYEPRGPWAKIHKDLSSLGSVHIS
NVHILANLEPWRWSSPDFIQKSVKAMHSVHGANALHIYPQANYWDWPYTA
DKLANGEREEQVYRDWAWYKAWGRYAWKADRNRLEEIKYWDKQFGDFYGI
PAEMADNIRIAYEESGEIAPKLLRRFGITEGNRQTLLLGMFMSQFVNPYK
YTIHYGFYESCGPGGEKLIEYVEKEWKKQPHVGELPLDIINQVIEHGDKA
VAAIDKVVSSAKKNSDELRRLQNDMHCYREYAYAFYYKVKAAQHVLNYHW
GKNMDELDKAVPLMEESLKHYTKLVDLTKDTYLFANSMQTAQRRIPIGGD
DGNNKTWSEMLVHYKAELYNFKENIEMLKDKKVRKCVEVTPLKEADVKIL
NNLTKVKIEKGAKIFSNIDGGIDAIAKEITGLTGFVFNGEKQRDDATTIE
FECSSPVTMLVAYFKDDHRKFAKAPRLESDASANDYGQAEPVLTNALHVK
GVALADIYPYKFKAGRHTLILPKGYCGVLGFTEDKIKERDVAPDWLFY
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain6hzf Chain B Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hzf Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		Y154 Y241 E294 R332 H334 K357 E361 H391
Binding residue
(residue number reindexed from 1)		Y116 Y203 E256 R294 H296 K319 E323 H353
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hzf, PDBe:6hzf, PDBj:6hzf
PDBsum6hzf
PubMed30877196
UniProtA0A4V8GZY4

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