Structure of PDB 6hyy Chain B Binding Site BS01

Receptor Information

>6hyy Chain B (length=217) Species: 9606 (Homo sapiens)

SELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGG
AVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQ
VFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAE
SGGKGKVIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQ
VKDNAKWYITDFVELLG

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6hyy Chain B Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hyy Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.
• Resolution: 1.566 Å
• Binding residue (original residue number in PDB): D20 D22 D179
• Binding residue (residue number reindexed from 1): D16 D18 D175
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.3: phosphoserine phosphatase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0016787 hydrolase activity
• GO:0036424 L-phosphoserine phosphatase activity
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001701 in utero embryonic development
• GO:0006563 L-serine metabolic process
• GO:0006564 L-serine biosynthetic process
• GO:0009612 response to mechanical stimulus
• GO:0031667 response to nutrient levels
• GO:0033574 response to testosterone

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6hyy, PDBe:6hyy, PDBj:6hyy
• PDBsum: 6hyy
• PubMed: 31205021
• UniProt: P78330|SERB_HUMAN Phosphoserine phosphatase (Gene Name=PSPH)