Structure of PDB 6hfa Chain B Binding Site BS01

Receptor Information
>6hfa Chain B (length=87) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGAPSFSVKEHRKIYTMIYRNLVVVN
Ligand information
Receptor-Ligand Complex Structure
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PDB6hfa Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		L54 G58 I61 M62 Y67 Q72 H73 V93 H96
Binding residue
(residue number reindexed from 1)		L30 G34 I37 M38 Y43 Q48 H49 V69 H72
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6hfa, PDBe:6hfa, PDBj:6hfa
PDBsum6hfa
PubMed32935897
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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