Structure of PDB 6h8q Chain B Binding Site BS01

Receptor Information
>6h8q Chain B (length=873) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TELFDILSTSEDVSIEELLREWLETYSENRDKFLQEFINLLLNCCGSVAR
VEDHDVHSNESSNETIGEIQLLFQRQKLHEFYLLISKENKKRKNFKMGPL
YQNFAEFMTKLLEVANDLQLLYVGNLVLDLLTWLSSFSVCKIRCFRYIST
LTLYLFQDYLTQQAVNLEKNYLAKLSKQLSLEEKKKRPNNKTLEKLESTI
AETQGSKVVIDSIIDNIVKLCFVHRYKDVSDLIRSESMLHLSIWIKNYPE
YFLKVTFLKYFGWLLSDNSVSVRLQVTKILPHLIIQNSAIRQVFERFKTK
ILEVAIRDVNLDVRIHSIQVLTEASSLGYLDDSEILIISSLMFDEEFDPF
KTSSFNKRSKFLSTVAKFLARVIKEKFDEFIKTHEDLPKEVDGLEVGPVV
QVGIFIKILNDSLIYHLKDCAEVDSRTKIRMLTQAAEFLSPYISTHLKTI
CNLLISDTESNELIPIDRNSTILYLNVFHGLCAGANNPKIQTKDSVKEIV
LPLFYDLLNAASIESADILCPLLESFITFSLDDWISIGYETELKKITDKT
IKAFMDSTIGNSKVDMKYDIFAKFIHHIHHFEKKELQEKFLNQIATLKIH
LKKFLQEKMDPNNSRDDYKDLTCSLYELYINKLTILGRDYPIEVDEELLQ
LFLNNFVSRIPIMFQDFDDSTAQEINFKMLVLLATWNLEKWREIIEKVRK
DLRSVWKPIAAIIGRLNTLVISLAATNETFENINSLFYLKWSACTSLMDI
IVAIKIFELKLPADATTWRYSMSEQFPFYLHDNASKVLLKIFLYLESLFA
KQVDVQLERVADEDANLNDLPETGFFENIETEFLLFTVKLKGLMKLNILD
ERFASRVALNKEKLGPLFKKIVD
Ligand information
>6h8q Chain H (length=27) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FTTKRLWSEITESMSYLPDPILKNFLS
Receptor-Ligand Complex Structure
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PDB6h8q Structural basis for Scc3-dependent cohesin recruitment to chromatin.
Resolution3.631 Å
Binding residue
(original residue number in PDB)		Y748 D749 H756 R818 L862 T865 R872 I943 E1017 T1018 L1022 K1026 L1054
Binding residue
(residue number reindexed from 1)		Y568 D569 H576 R638 L682 T685 R692 I756 E830 T831 L835 K839 L867
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006473 protein acetylation
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0034089 establishment of meiotic sister chromatid cohesion
GO:0051301 cell division
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008278 cohesin complex
GO:0030892 mitotic cohesin complex
GO:0030893 meiotic cohesin complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6h8q, PDBe:6h8q, PDBj:6h8q
PDBsum6h8q
PubMed30109982
UniProtP40541|SCC3_YEAST Cohesin subunit SCC3 (Gene Name=IRR1)

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