Structure of PDB 6h0b Chain B Binding Site BS01

Receptor Information
>6h0b Chain B (length=521) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLS
DRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHS
VLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGL
VRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVID
TIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSP
TMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPC
SHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYG
DISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSEC
LDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVP
EQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGR
PDVQMRTCDALDKNQIWSFEK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6h0b Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		T258 Q269 F284 W286 W334 F364 A368 R372
Binding residue
(residue number reindexed from 1)		T201 Q212 F227 W229 W277 F307 A311 R315
Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h0b, PDBe:6h0b, PDBj:6h0b
PDBsum6h0b
PubMed30276263
UniProtQ8N4A0|GALT4_HUMAN Polypeptide N-acetylgalactosaminyltransferase 4 (Gene Name=GALNT4)

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