Structure of PDB 6gy2 Chain B Binding Site BS01
Receptor Information
>6gy2 Chain B (length=224) Species:
9606
(Homo sapiens) [
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DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSSR
Ligand information
>6gy2 Chain C (length=12) Species:
9606
(Homo sapiens) [
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ATPPTLSSTVLI
Receptor-Ligand Complex Structure
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PDB
6gy2
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Resolution
3.11 Å
Binding residue
(original residue number in PDB)
K413 W414 V415 D416 Y417 Y485 H489 L490 L491 H538 K540
Binding residue
(residue number reindexed from 1)
K43 W44 V45 D46 Y47 Y115 H119 L120 L121 H168 K170
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:6gy2
,
PDBe:6gy2
,
PDBj:6gy2
PDBsum
6gy2
PubMed
32286328
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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