Structure of PDB 6gx9 Chain B Binding Site BS01

Receptor Information
>6gx9 Chain B (length=911) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLL
QIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLS
PVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLP
EEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKV
FRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCS
ALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTE
LCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGE
HLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRM
RVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSV
DPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDP
VLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSF
LLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQSSD
PTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNR
IVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSIL
VDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLAT
RFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGV
ANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVL
WEIMQVDRPTFCRWLENSLKGLPKEVTVTHKQLTDFHKQVTSAEECKQVC
WALRDFTRLFR
Ligand information
Receptor-Ligand Complex Structure
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PDB6gx9 Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N656 R657 E660 R661 R664 R671 C699 Y702 D709 D747 D750 D751 R754 R758 R797
Binding residue
(residue number reindexed from 1)		N649 R650 E653 R654 R657 R664 C692 Y695 D702 D740 D743 D744 R747 R751 R790
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gx9, PDBe:6gx9, PDBj:6gx9
PDBsum6gx9
PubMed30916345
UniProtQ9Y5L0|TNPO3_HUMAN Transportin-3 (Gene Name=TNPO3)

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