Structure of PDB 6g5k Chain B Binding Site BS01
Receptor Information
>6g5k Chain B (length=424) Species:
1491
(Clostridium botulinum) [
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ILNNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKI
RVTQNQNIIFNSVFLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMKNN
SGWKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITN
NLNNAKIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYF
SIFNTELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSY
IKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKSDDIVRKED
YIYLDFFNLNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDE
QPTYSCQLLFKKDEESTDEIGLIGIHRFYEFEEYKDYFCISKWYLKEVKR
KPYNLKLGCNWQFIPKDEGWTELQ
Ligand information
>6g5k Chain 33 (length=15) Species:
9606
(Homo sapiens) [
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DAFSKLKEKFMNELH
Receptor-Ligand Complex Structure
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PDB
6g5k
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
S1116 W1178 Y1183 E1191 K1192 F1194 P1197 S1199 S1201 E1203
Binding residue
(residue number reindexed from 1)
S257 W313 Y318 E326 K327 F329 P332 S334 S336 E338
Enzymatic activity
Enzyme Commision number
3.4.24.69
: bontoxilysin.
Gene Ontology
Cellular Component
GO:0005576
extracellular region
View graph for
Cellular Component
External links
PDB
RCSB:6g5k
,
PDBe:6g5k
,
PDBj:6g5k
PDBsum
6g5k
PubMed
30746458
UniProt
P10844
|BXB_CLOBO Botulinum neurotoxin type B (Gene Name=botB)
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