Structure of PDB 6g5f Chain B Binding Site BS01

Receptor Information
>6g5f Chain B (length=845) Species: 1491 (Clostridium botulinum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APGICIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNYIENDFPINEL
ILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKIFTDENTIFQYL
YSQTFPLDIRDISLTSSFDDALLFSNKVYSFFSMDYIKTANKVVEAGLFA
GWVKQIVNDFVIEANKSNTMDKIADISLIVPYIGLALNVGNETAKGNFEN
AFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKTIDNALTKRNE
KWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIY
SEKEKSNINIDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLA
VEKLLDFDNTLKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLS
IYTNDTILIEMFNKYNSEILNNIILNLRYKDNNLIDLSGYGAKVEVYDGV
ELNDKNQFKLTSSANSKIRVTQNQNIINSVFLDFSVSFWIRIPKYKNDGI
QNYIHNEYTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEYNIR
EDISEYINRWFFVTITNNLNNAKIYINGKLESNTDIKDIREVIANGEIIF
KLDGDIDRTQFIWMKYFSIFNTELSQSNIEERYKIQSYSEYLKDFWGNPL
MYNKEYYMFNAGNKNSYIKLKKDSPVGEILTRSKYNQNSKYINYRDLYIG
EKFIIRRKSNSQSINDDIVRKEDYIYLDFFNLNQEWRVYTYKYFKKEEMK
LFLAPIYDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEESTDEIGLIGIHR
FYESGIYKDYFCISKWYLKEVKRKPYNLKLGCNWQFIPKDEGWTE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6g5f Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K1113 P1117 Y1183 K1192 F1194 Y1199 E1203 E1245
Binding residue
(residue number reindexed from 1)		K671 P675 Y741 K750 F752 Y757 E761 E803
Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0008320 protein transmembrane transporter activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0030430 host cell cytoplasm
GO:0044161 host cell cytoplasmic vesicle
GO:0044164 host cell cytosol
GO:0044221 host cell synapse
GO:0044231 host cell presynaptic membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6g5f, PDBe:6g5f, PDBj:6g5f
PDBsum6g5f
PubMed30746458
UniProtP10844|BXB_CLOBO Botulinum neurotoxin type B (Gene Name=botB)

[Back to BioLiP]