Structure of PDB 6fsa Chain B Binding Site BS01

Receptor Information
>6fsa Chain B (length=756) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDAEMAAFGEAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKATI
LSRGKVTAETEHGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLY
NLKERYASWMIYTYSGLFCVTINPYKWLPVYNAEVVAAYRGKKRSEAPPH
IFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGD
RTGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA
SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYD
YAFISQGETTVASIDDAEELMATDNAFDVLGFTTEEKNSMYKLTGAIMHF
GNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVTKGQN
VQQVVYAKGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFE
IFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMD
LQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSSNFQKP
RNIKPEAHFSLIHYAGTVDYNIIGWLQKNKDPLNETVVDLYKKSSLKMLS
SLFANYAGQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDN
PLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPDSRKG
AEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQ
SRGVLS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6fsa Chain B Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fsa Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition.
Resolution2.33 Å
Binding residue
(original residue number in PDB)		T185 S242
Binding residue
(residue number reindexed from 1)		T182 S233
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000146 microfilament motor activity
GO:0003774 cytoskeletal motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0007512 adult heart development
GO:0030049 muscle filament sliding
GO:0045214 sarcomere organization
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0032982 myosin filament

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6fsa, PDBe:6fsa, PDBj:6fsa
PDBsum6fsa
PubMed30275503
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

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