Structure of PDB 6fqq Chain B Binding Site BS01

Receptor Information
>6fqq Chain B (length=61) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINA
RRRLLPDMLRK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fqq TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		Y191 K197 R219 R220
Binding residue
(residue number reindexed from 1)		Y23 K29 R51 R52
Binding affinityPDBbind-CN: Kd=388.6nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqq, PDBe:6fqq, PDBj:6fqq
PDBsum6fqq
PubMed30060237
UniProtQ15583|TGIF1_HUMAN Homeobox protein TGIF1 (Gene Name=TGIF1)

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