Structure of PDB 6fky Chain B Binding Site BS01
Receptor Information
>6fky Chain B (length=266) Species:
7955
(Danio rerio) [
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SSDLTAFREHFAKAKHIAIITGAGVSAESGVPTFRGPGGFWRKWQAQDLA
TPEAFSRDPSLVWEFYHYRREVMRSKMPNPAHLAIAECEARLGQQGRSVV
IITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCGEVKANHKSPICPALDG
KGAPDPNTKEARIPVELLPRCERKSCNGLLRPHVVWFGETLDSDILTAVE
RELEKCDLCLVVGTSSIVYPAAMFAPQVASRGVPVAEFNMECTPATQRFK
YHFEGPCGSTLPPALE
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
6fky Chain B Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
6fky
Potent and Selective Inhibitors of Human Sirtuin 5.
Resolution
2.98 Å
Binding residue
(original residue number in PDB)
C162 C165 C203 C208
Binding residue
(residue number reindexed from 1)
C130 C133 C171 C176
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
P64 T65 F66 R67 N137 D139 H154
Catalytic site (residue number reindexed from 1)
P32 T33 F34 R35 N105 D107 H122
Enzyme Commision number
2.3.1.-
Gene Ontology
Molecular Function
GO:0000035
acyl binding
GO:0008270
zinc ion binding
GO:0016740
transferase activity
GO:0017136
NAD-dependent histone deacetylase activity
GO:0034979
NAD-dependent protein lysine deacetylase activity
GO:0036054
protein-malonyllysine demalonylase activity
GO:0036055
protein-succinyllysine desuccinylase activity
GO:0046872
metal ion binding
GO:0061697
protein-glutaryllysine deglutarylase activity
GO:0070403
NAD+ binding
GO:1901363
heterocyclic compound binding
Biological Process
GO:0006338
chromatin remodeling
GO:0006476
protein deacetylation
GO:0010566
regulation of ketone biosynthetic process
GO:0036047
peptidyl-lysine demalonylation
GO:0036048
protein desuccinylation
GO:0036049
peptidyl-lysine desuccinylation
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6fky
,
PDBe:6fky
,
PDBj:6fky
PDBsum
6fky
PubMed
29494161
UniProt
Q6DHI5
|SIR5_DANRE NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=sirt5)
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