Structure of PDB 6f8y Chain B Binding Site BS01

Receptor Information
>6f8y Chain B (length=340) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKR
IFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVL
PKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPS
PTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPL
EEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKV
RRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALR
HMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH
Ligand information
Ligand IDTHR
InChIInChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChIKeyAYFVYJQAPQTCCC-GBXIJSLDSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)C(O)C
OpenEye OEToolkits 1.5.0CC(C(C(=O)O)N)O
CACTVS 3.341C[CH](O)[CH](N)C(O)=O
CACTVS 3.341C[C@@H](O)[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0C[C@H]([C@@H](C(=O)O)N)O
FormulaC4 H9 N O3
NameTHREONINE
ChEMBLCHEMBL291747
DrugBankDB00156
ZINCZINC000000895103
PDB chain6f8y Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6f8y Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		T35 V36 R121 E180 S181 R195
Binding residue
(residue number reindexed from 1)		T34 V35 R120 E179 S180 R194
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.7.87: L-threonylcarbamoyladenylate synthase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0061710 L-threonylcarbamoyladenylate synthase
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006450 regulation of translational fidelity
GO:0008033 tRNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6f8y, PDBe:6f8y, PDBj:6f8y
PDBsum6f8y
PubMed29650678
UniProtQ9UYB2|SUA5_PYRAB Threonylcarbamoyl-AMP synthase (Gene Name=sua5)

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