Structure of PDB 6f5e Chain B Binding Site BS01

Receptor Information
>6f5e Chain B (length=346) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNNFYSVEIGDSTFTVLKRYQNLKPIIVCAAYDAILERNVAIKKLSRPFQ
NQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMD
ANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD
CTLKILDFGLARTAGTSFMVVTRYYRAPEVILGMGYKENVDLWSVGCIMG
EMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKY
AGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL
QHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f5e Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Q117 M121 R127 Y130 S161 D162 C163 W324 E329
Binding residue
(residue number reindexed from 1)		Q105 M109 R115 Y118 S149 D150 C151 W308 E313
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D139 K141 N144 D157 T172
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6f5e, PDBe:6f5e, PDBj:6f5e
PDBsum6f5e
PubMed
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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