Structure of PDB 6evk Chain B Binding Site BS01

Receptor Information
>6evk Chain B (length=748) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNMITQRT
IGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYF
VELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITG
DNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRG
YMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLS
PGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGH
FKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVAN
FSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKD
YRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNL
HIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKSLE
YDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYR
RPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6evk Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		N671 R672 S673 I674 N676
Binding residue
(residue number reindexed from 1)		N665 R666 S667 I668 N670
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6evk, PDBe:6evk, PDBj:6evk
PDBsum6evk
PubMed29202182
UniProtH6QM91

[Back to BioLiP]