Structure of PDB 6esl Chain B Binding Site BS01

Receptor Information

>6esl Chain B (length=360) Species: 446 (Legionella pneumophila)

VHEQLQVPQCLAAKITVPHKILAENKEFKIIDVLSSDVETLTILADKVSC
GHFVNVSHKLQQQSAQKLLQGVSKLHKDVYEIKHEEEVNAALKEIVSDNI
WQTLTHMTSYYNRSATKDTGVETANWLKSKFEQMAVEYGRTDTSTFFVKT
GWYKQPSLVTVIGKDIKAPAIVIGAHMDTLDGRMPGAGDDGSGSSSIMEA
ARVILSSKTTFKRPIYFIWYAAEERGLVGSQHVVQHFQEQSIPVKAVVQF
DMTGYRNDANDPTMWVFTDYTDRDLSNYLAKLIDHYIHVPVDYSRCGYGC
SDHASWNEEDIPAAFPCETSFADHNPYIHTSSDKMDLLNLEHMTNFSKLA
VAFAIELASE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6esl Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6esl Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition duringLegionella pneumophilaIntracellular Infection of Amoebas.
• Resolution: 1.87 Å
• Binding residue (original residue number in PDB): D207 E242
• Binding residue (residue number reindexed from 1): D189 E224
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H194 D207 E241 E242 D269 H347
• Catalytic site (residue number reindexed from 1): H176 D189 E223 E224 D251 H329
• Enzyme Commision number: 3.4.11.10: bacterial leucyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6esl, PDBe:6esl, PDBj:6esl
• PDBsum: 6esl
• PubMed: 29666285
• UniProt: Q5ZRR6