Structure of PDB 6erg Chain B Binding Site BS01

Receptor Information

>6erg Chain B (length=531) Species: 9606 (Homo sapiens)

MHHHHHHHHHHENLYFQGVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQ
AKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHL
MLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIE
IFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKGITEQQKEGLEI
VKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNL
SIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLETEVLKEDII
QGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQV
LKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPH
IKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSM
SLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQH
IWNMLNPPAEVTTKSQIPLSKIKTLFPLIEA

Ligand information

>6erg Chain F (length=7) Species: 9606 (Homo sapiens)

KPRGLFS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6erg XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): H-14 F41 H131 E133 Q162 F164 E216 E223 Y225 K233 L234 K238
• Binding residue (residue number reindexed from 1): H3 F58 H148 E150 Q179 F181 E209 E216 Y218 K226 L227 K231

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0003684 damaged DNA binding
• GO:0042162 telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0006303 double-strand break repair via nonhomologous end joining
• GO:0006310 DNA recombination

Cellular Component

• GO:0005634 nucleus
• GO:0043564 Ku70:Ku80 complex

External links

• PDB: RCSB:6erg, PDBe:6erg, PDBj:6erg
• PDBsum: 6erg
• PubMed: 30291363
• UniProt: P13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)