Structure of PDB 6e2p Chain B Binding Site BS01

Receptor Information
>6e2p Chain B (length=443) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VYLYHSLEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETER
IWYPPNHVFHHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFV
MSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLA
IYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFKATARNLKL
KYLINLETLQSAFYTEKFEVKEPIFATIIITGNGGIQWSRGKHKESETLT
EQDLQLYCDFPNIIDVSIKSRVVTIHKQDGKNLEIELSSLREALSFVSLI
DGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQ
TGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKK
NFSSLKDLLNCYQMETVRNIIFQFTKCCPPKPKDKSNLLVFRT
Ligand information
Receptor-Ligand Complex Structure
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PDB6e2p Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
Resolution2.83 Å
Binding residue
(original residue number in PDB)		H172 E176 E177 L179 G180 L184 Y221 H222 R232 N257
Binding residue
(residue number reindexed from 1)		H123 E127 E128 L130 G131 L135 Y172 H173 R183 N205
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0042393 histone binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e2p, PDBe:6e2p, PDBj:6e2p
PDBsum6e2p
PubMed30044226
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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