Structure of PDB 6dtn Chain B Binding Site BS01

Receptor Information
>6dtn Chain B (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHSSGLVPRGSTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSI
DINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMV
DITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGH
LTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVV
RRIICSAGLSLLAEERQENLPDEIYHVYSFALR
Ligand information
Receptor-Ligand Complex Structure
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PDB6dtn Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.
Resolution1.475 Å
Binding residue
(original residue number in PDB)		W20 M30 L31 Y34 G69 G71 R74 I75 D91 I92 T93 F96 G118 L119 W136 V137 H140 N168 D177 D180 E213 I214 Y215
Binding residue
(residue number reindexed from 1)		W30 M40 L41 Y44 G79 G81 R84 I85 D101 I102 T103 F106 G128 L129 W146 V147 H150 N178 D187 D190 E223 I224 Y225
Enzymatic activity
Enzyme Commision number 2.1.1.244: protein N-terminal methyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0071885 N-terminal protein N-methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006480 N-terminal protein amino acid methylation
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0018012 N-terminal peptidyl-alanine trimethylation
GO:0018013 N-terminal peptidyl-glycine methylation
GO:0018016 N-terminal peptidyl-proline dimethylation
GO:0032259 methylation
GO:0035572 N-terminal peptidyl-serine dimethylation
GO:0035573 N-terminal peptidyl-serine trimethylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dtn, PDBe:6dtn, PDBj:6dtn
PDBsum6dtn
PubMed30883119
UniProtQ9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Gene Name=NTMT1)

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