Structure of PDB 6dlu Chain B Binding Site BS01

Receptor Information
>6dlu Chain B (length=734) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDLIPLVNRLQDAFLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV
TRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKG
ISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFV
TKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGT
DARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPS
YRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEY
KNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINR
IFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVK
KQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHI
REREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGN
QDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYM
LSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVD
SWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRN
LVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTL
MEESAEQAQRRDEMLRMYHALKEALSIIGDINTT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6dlu Chain B Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6dlu Cryo-EM of the dynamin polymer assembled on lipid membrane.
Resolution3.75 Å
Binding residue
(original residue number in PDB)		S45 T65
Binding residue
(residue number reindexed from 1)		S31 T51
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6dlu, PDBe:6dlu, PDBj:6dlu
PDBsum6dlu
PubMed30069048
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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