Structure of PDB 6dhw Chain B Binding Site BS01

Receptor Information
>6dhw Chain B (length=166) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLE
QALQFWKQESYNIRHSFRTDYTPFSCLKIILSNPPSQGDYHGCPFRHSDP
ELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKYFEMIHNVDDCGFSL
NHPNQFFCESQRILNG
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6dhw Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6dhw Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.
Resolution2.013 Å
Binding residue
(original residue number in PDB)		P285 C287 C367 C384 F386 Q421 C424 P444
Binding residue
(residue number reindexed from 1)		P14 C16 C76 C93 F95 Q130 C133 P153
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:6dhw, PDBe:6dhw, PDBj:6dhw
PDBsum6dhw
PubMed30562384
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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