Structure of PDB 6cxo Chain B Binding Site BS01

Receptor Information
>6cxo Chain B (length=449) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIPIDCRMSPWSEWSECDPCLKQRFRSRSILAFGQFNGKSCVDVLGDRQG
CEPTQECENCGNDFQCETGRCIKRRLLCNGDNDCGDYSDENDCDPRTPCR
DRVAEESELGLTAGYGINILGMEPLRTPFDNEFYNGLCDRVRDEKTYYRK
PWNVVSLIYETKADKSFRTENYDEHLEVFKAINRDFALKFSATEVPKFSY
FMGKNFRRLSSYFSQSKKMFVHLRGVVQLGRFVMRNRDVVLRSTFLDDVK
ALPTSYEKGEYFGFLETYGTHYSTSGSLGGQYEIVYVLDKASMKEKGVDL
NDVKHCLGFNMDGCIKKTVDITRDNIIDDVISFIRGGTREQAILLKEKIL
RGDKTFDKTDFANWASSLANAPALISQRMSPIYNLIPLKIKDAYIKKQNL
EKAVEDYIDEFSTKRCYPCLNGGTIILLDGQCLCSCPMMFRGMACEIHQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6cxo Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cxo The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		L95 N98 D100 D102 D108 E109
Binding residue
(residue number reindexed from 1)		L76 N79 D81 D83 D89 E90
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0001906 cell killing
GO:0006955 immune response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0044218 other organism cell membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6cxo, PDBe:6cxo, PDBj:6cxo
PDBsum6cxo
PubMed30111885
UniProtP06683|CO9_MOUSE Complement component C9 (Gene Name=C9)

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