Structure of PDB 6cs3 Chain B Binding Site BS01

Receptor Information
>6cs3 Chain B (length=240) Species: 42789 (enterovirus D68) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVPTYLLPGSGQFLTTDDHSSAPALPCFNPTPEMHIPGQVRNMLEVVQVE
SMMEINNTESAVGMERLKVDISALTDVDQLLFNIPLDIQLDGPLRNTLVG
NISRYYTHWSGSLEMTFMFCGSFMAAGKLILCYTPPGGSCPTTRETAMLG
THIVWDFGLQSSVTLIIPWISGSHYRMFNNNANVGYVTCFMQTNLIVPSE
SSDTCSLIGFIAAKDDFSLRLMRDSPDIGQHLHAAEAAYQ
Ligand information
>6cs3 Chain D (length=28) Species: 42789 (enterovirus D68) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NFYKDSYAASASKQDFSQDPSKFTEPVV
Receptor-Ligand Complex Structure
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PDB6cs3 Molecular basis for the acid-initiated uncoating of human enterovirus D68.
Resolution3.31 Å
Binding residue
(original residue number in PDB)		D18 S20 S21 A22 P23 L25 C27 R41 N42 E45 Q48
Binding residue
(residue number reindexed from 1)		D18 S20 S21 A22 P23 L25 C27 R41 N42 E45 Q48
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:6cs3, PDBe:6cs3, PDBj:6cs3
PDBsum6cs3
PubMed30530701
UniProtA0A097BW12

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