Structure of PDB 6crn Chain B Binding Site BS01

Receptor Information
>6crn Chain B (length=332) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL
NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGC
QELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRND
SIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMPKKPFVKLKDC
IELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSDK
LDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGHYTAFAKNKDD
GKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6crn Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6crn Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C448 C451 C502
Binding residue
(residue number reindexed from 1)		C167 C170 C221
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6crn, PDBe:6crn, PDBj:6crn
PDBsum6crn
PubMed30713027
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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