Structure of PDB 6cpn Chain B Binding Site BS01

Receptor Information

>6cpn Chain B (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DTRPRFLEYSTSECHFFNGTERVRFLDRYFYNQEEYVRFDSDVGEFRAVT
ELGRPDEEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVHPKVTV
YPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA

Ligand information

>6cpn Chain C (length=13) Species: 11706 (HIV-1 M:B_HXB2R) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RFYKTLRAEQASQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6cpn CD4+T cell-mediated HLA class II cross-restriction in HIV controllers.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	S13 F26 D57 Y60 W61 F67 D70 R71 Y78 H81 N82 V85
Binding residue (residue number reindexed from 1)	S12 F25 D56 Y59 W60 F66 D69 R70 Y77 H80 N81 V84

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:6cpn, PDBe:6cpn, PDBj:6cpn
PDBsum	6cpn
PubMed	29884618
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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