Structure of PDB 6cf6 Chain B Binding Site BS01
Receptor Information
>6cf6 Chain B (length=319) Species:
10090
(Mus musculus) [
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DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTP
LHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLL
KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV
DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSH
ETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHND
VMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL
QGFTAAQMGNEAVQQILSE
Ligand information
>6cf6 Chain C (length=12) Species:
9606
(Homo sapiens) [
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LARESSADGADS
Receptor-Ligand Complex Structure
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PDB
6cf6
Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.
Resolution
1.93 Å
Binding residue
(original residue number in PDB)
R361 S363 L368 G371 Y372 K393 N401 Y405 H407 D425 W427 F429 E434 R440
Binding residue
(residue number reindexed from 1)
R46 S48 L53 G56 Y57 K78 N86 Y90 H92 D110 W112 F114 E119 R125
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:6cf6
,
PDBe:6cf6
,
PDBj:6cf6
PDBsum
6cf6
PubMed
29604130
UniProt
Q6PFX9
|TNKS1_MOUSE Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=Tnks)
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