Structure of PDB 6c1r Chain B Binding Site BS01

Receptor Information

>6c1r Chain B (length=371) Species: 562,9606

LEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAKDFRHGFDILVG
QIDDALKLANEGKVKEAQAAAEQLKTTRNAYSNTLRVPDILALVIFAVVF
LVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQ
HHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFR
GAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRR
ERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRSTKTLKVVVAVVASF
FIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYV
VAGQGFKSLPSLLRNVLTEES

Ligand information

>6c1r Chain L (length=6) Species: 32630 (synthetic construct)

FPPAWR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6c1r Orthosteric and allosteric action of the C5a receptor antagonists.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): L178 S181 P199 R261 R264 C274 G275 V276 S279 Y344 G348 M351 K365 D368 V372
• Binding residue (residue number reindexed from 1): L144 S147 P165 R227 R230 C240 G241 V242 S245 Y307 G311 M314 K328 D331 V335

Gene Ontology

Molecular Function

• GO:0004875 complement receptor activity
• GO:0004930 G protein-coupled receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006935 chemotaxis
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:6c1r, PDBe:6c1r, PDBj:6c1r
• PDBsum: 6c1r
• PubMed: 29867214
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  P21730|C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (Gene Name=C5AR1)