Structure of PDB 6c07 Chain B Binding Site BS01

Receptor Information

>6c07 Chain B (length=368) Species: 353152 (Cryptosporidium parvum Iowa II)

QFLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVACETCTKTGFIM
VFGEITTKANVNYERVVRETVKEIGYDSEEKGLDYKTMDVIIKLEQQKNV
EDIGAGDQGMMFGYATNETKELMPLTHVLATSITRELDYIRVKGWLRPDG
KAQVTVEYNCKHGVLIPKRIHTILVSVQHDENIENEEIREFVLENVIKKV
CPSDLMDKETRILINPSGRFTIGGPAADAGLTGRKIIVDTYGGWGAHGGG
AFSGKDATKVDRSGAYMARLVAKSIVFSGLCSRCLVQVSYGIGIARPLSL
YINTFGTAKDGYNDAKLLEIVNKVFDFRPGILIKQLNLKSPIFKKTSSGG
HFGRSEEEFLWEKPIILQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6c07 Chain B Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6c07 Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): D266 A267
• Binding residue (residue number reindexed from 1): D228 A229
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H34 D36 K37 E62 E75 K189 F258 D266 A267 R272 K273 K293 K297 D299
• Catalytic site (residue number reindexed from 1): H13 D15 K16 E41 E54 K151 F220 D228 A229 R234 K235 K255 K259 D261
• Enzyme Commision number: 2.5.1.6: methionine adenosyltransferase.

Gene Ontology

Molecular Function

• GO:0004478 methionine adenosyltransferase activity
• GO:0005524 ATP binding
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006556 S-adenosylmethionine biosynthetic process
• GO:0006730 one-carbon metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:6c07, PDBe:6c07, PDBj:6c07
• PDBsum: 6c07
• PubMed: 30950830
• UniProt: Q5CYE4