Structure of PDB 6bwy Chain B Binding Site BS01

Receptor Information
>6bwy Chain B (length=346) Species: 9606,284812 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLNELLNAGEYKIGELTFQSIRSSQELQKKNTIVNLFGIVKDFTPSRQSL
HGTKDWVTTVYLWDPTCDTSSIGLQIHLFSKQGNDLPVIKQVGQPLLLHQ
ITLRSYRDRTQGLSKDQFRYALWPDFSSNSKDTLCPQPMPRLMKTGDKEE
QFALLLNKIWDEQTNHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHN
DTWVKLNQRRGFLANQAPEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSW
SPCFSCAQEMAKFISKNKHVSLCIKTARIYDDQGRAQEGLRTLAEAGAKI
SIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bwy Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Q318 Q322 R326
Binding residue
(residue number reindexed from 1)		Q283 Q287 R291
Binding affinityPDBbind-CN: Kd=26uM
Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0000723 telomere maintenance
Cellular Component
GO:0000781 chromosome, telomeric region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bwy, PDBe:6bwy, PDBj:6bwy
PDBsum6bwy
PubMed29596531
UniProtO13988|POT1_SCHPO Protection of telomeres protein 1 (Gene Name=pot1);
Q9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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