Structure of PDB 6bn8 Chain B Binding Site BS01

Receptor Information
>6bn8 Chain B (length=375) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIP
GQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYA
YREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPST
MSAVQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAET
LMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIG
SAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNP
HGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKF
TATKKDMSPQKFWGLTRSALLPTIP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6bn8 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bn8 Plasticity in binding confers selectivity in ligand-induced protein degradation.
Resolution3.99004 Å
Binding residue
(original residue number in PDB)		C323 C326 C391
Binding residue
(residue number reindexed from 1)		C271 C274 C339
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6bn8, PDBe:6bn8, PDBj:6bn8
PDBsum6bn8
PubMed29892083
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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