Structure of PDB 6bmc Chain B Binding Site BS01

Receptor Information

>6bmc Chain B (length=380) Species: 287 (Pseudomonas aeruginosa)

MDDLLQRVRRCEALQQPEWGDPSRLRDVQAYLRGSPALIRAGDILALRAT
LARVARGEALVVQCGDCAEDMDDHHAENVARKAAVLELLAGALRLAGRRP
VIRVGRIAGQYAKPRSKPHEQEQTLPVYRGDMVNGREAHAEQRRADPQRI
LKGYAAARNIMRHLGWDAASPVWTSHEMLLLDYELSMLREDEQRRVYLGS
THWPWIGERTRQVDGAHVALLAEVLNPVACKVGPEIGRDQLLALCERLDP
RREPGRLTLIARMGAQKVGERLPPLVEAVRAAGHPVIWLSDPMHGNTIVA
PCGNKTRLVRSIAEEVAAFRLAVSGSGGVAAGLHLETTPDDVTECVADSS
GLHQVSRHYTSLCDPRLNPWQALSAVMAWS

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 6bmc Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6bmc Structural and functional characterisation of the entry point to pyocyanin biosynthesis inPseudomonas aeruginosadefines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): C67 H303 E345 D373
• Binding residue (residue number reindexed from 1): C67 H294 E336 D364
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.

Gene Ontology

Molecular Function

• GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
• GO:0016740 transferase activity

Biological Process

• GO:0009073 aromatic amino acid family biosynthetic process

External links

• PDB: RCSB:6bmc, PDBe:6bmc, PDBj:6bmc
• PDBsum: 6bmc
• PubMed: 30242059
• UniProt: G3XCJ9