Structure of PDB 6bkj Chain B Binding Site BS01

Receptor Information
>6bkj Chain B (length=307) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICE
NPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIE
NYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEK
AYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIE
RGSLMGCSIDDGTRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWG
QVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKL
EICNLTA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bkj Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G127 C129 G221 G222 H334
Binding residue
(residue number reindexed from 1)		G70 C72 G164 G165 H223
Enzymatic activity
Catalytic site (original residue number in PDB) Q123 C129 H334 N358 W360
Catalytic site (residue number reindexed from 1) Q66 C72 H223 N247 W249
Enzyme Commision number 3.4.22.54: calpain-3.
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bkj, PDBe:6bkj, PDBj:6bkj
PDBsum6bkj
PubMed29382717
UniProtP20807|CAN3_HUMAN Calpain-3 (Gene Name=CAPN3)

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