Structure of PDB 6bir Chain B Binding Site BS01

Receptor Information
>6bir Chain B (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVT
ELGRPSAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVYPEVTV
YPAKTQPHNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWT
FQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bir The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H13 Y30 Y47 S57 Y60 W61 L67 Q70 R71 A74 Y78 H81 N82 V85
Binding residue
(residue number reindexed from 1)		H12 Y29 Y46 S56 Y59 W60 L66 Q69 R70 A73 Y77 H80 N81 V84
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6bir, PDBe:6bir, PDBj:6bir
PDBsum6bir
PubMed29317506
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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