Structure of PDB 6ank Chain B Binding Site BS01

Receptor Information
>6ank Chain B (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKK
HKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDP
IGEVSIPLNKVDLTQMQTFWKDLKPSRGELLLSLCYNPSANSIIVNIIKA
RNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFD
IPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIAR
PRQPVAQWHQLKA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ank Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ank Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Resolution2.254 Å
Binding residue
(original residue number in PDB)		D166 D172 D225 Y226 D227
Binding residue
(residue number reindexed from 1)		D32 D38 D91 Y92 D93
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005544 calcium-dependent phospholipid binding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6ank, PDBe:6ank, PDBj:6ank
PDBsum6ank
PubMed28923929
UniProtQ62747|SYT7_RAT Synaptotagmin-7 (Gene Name=Syt7)

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