Structure of PDB 6agm Chain B Binding Site BS01
Receptor Information
>6agm Chain B (length=334) Species:
83333
(Escherichia coli K-12) [
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DALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDP
RLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTV
GWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQY
LGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRA
AAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKE
MEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIE
SNIHEGDACISWEMTDALLREIHQDLNGQLTARV
Ligand information
Ligand ID
TYR
InChI
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKey
OUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
Software
SMILES
ACDLabs 10.04
O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0
c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0
c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341
N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341
N[C@@H](Cc1ccc(O)cc1)C(O)=O
Formula
C9 H11 N O3
Name
TYROSINE
ChEMBL
CHEMBL925
DrugBank
DB00135
ZINC
ZINC000000266964
PDB chain
6agm Chain B Residue 601 [
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Receptor-Ligand Complex Structure
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PDB
6agm
Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
P148 P151 Q152 L180 S181 F210 G212 I213 L222
Binding residue
(residue number reindexed from 1)
P145 P148 Q149 L177 S178 F207 G209 I210 L219
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.5.1.54
: 3-deoxy-7-phosphoheptulonate synthase.
Gene Ontology
Molecular Function
GO:0003849
3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740
transferase activity
GO:0042802
identical protein binding
Biological Process
GO:0008652
amino acid biosynthetic process
GO:0009058
biosynthetic process
GO:0009073
aromatic amino acid family biosynthetic process
GO:0009423
chorismate biosynthetic process
Cellular Component
GO:0005737
cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6agm
,
PDBe:6agm
,
PDBj:6agm
PDBsum
6agm
PubMed
30946901
UniProt
P00888
|AROF_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive (Gene Name=aroF)
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