Structure of PDB 6agi Chain B Binding Site BS01

Receptor Information
>6agi Chain B (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEDLDLYATSRERRFRLFASIECEGQLFMTPYDFILAVTTDEPKVAKWKS
LSKQELNQMLAETPPVWKGSSKLFRNLKEKGVISYTEYLFLLCILTKPHA
GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEEKRAMLRL
QLYGYLVTDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIEFLSYS
NGMNTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITFDEFRSFF
QFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLVNTVFK
IFDVDKDDQLSYKEFIGIMKDR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6agi Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6agi Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter.
Resolution2.799 Å
Binding residue
(original residue number in PDB)		D245 D247 N249 M251 D253 E256
Binding residue
(residue number reindexed from 1)		D110 D112 N114 M116 D118 E121
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0006851 mitochondrial calcium ion transmembrane transport

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6agi, PDBe:6agi, PDBj:6agi
PDBsum6agi
PubMed30699349
UniProtQ86XE3|MICU3_HUMAN Calcium uptake protein 3, mitochondrial (Gene Name=MICU3)

[Back to BioLiP]