Structure of PDB 6a8g Chain B Binding Site BS01

Receptor Information
>6a8g Chain B (length=244) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGEFTEVENQPWFAAIYQKNSPPSFKCGGSLISPCWVASAAHCFIQLP
KKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLK
IRTSTGQCAQPSRSIQTIALPPRFTDAPFGSDCEITGFGKESESDYLYPK
NLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPL
ICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIG
Ligand information
>6a8g Chain E (length=10) Species: 279974 (Phage display vector pTDisp) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CPAYSRYIGC
Receptor-Ligand Complex Structure
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PDB6a8g Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		K41 H57 E96 S97A L97B Y99 Y151 D189 S190 C191 K192 S195 W215 G216 R217 G218
Binding residue
(residue number reindexed from 1)		K28 H44 E87 S89 L90 Y92 Y148 D190 S191 C192 K193 S196 W216 G217 R218 G219
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H44 D95 K193 G194 D195 S196 G197
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6a8g, PDBe:6a8g, PDBj:6a8g
PDBsum6a8g
PubMed30707839
UniProtP06869|UROK_MOUSE Urokinase-type plasminogen activator (Gene Name=Plau)

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