Structure of PDB 6a5o Chain B Binding Site BS01

Receptor Information
>6a5o Chain B (length=1161) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRN
LTYSSPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYK
MKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIR
SALEKGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALG
VVPDGEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSA
ALGIRREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCA
LERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETD
RDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYS
STLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNL
SLLSGISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGI
HRDPSMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFI
VEDDESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEE
EETIMIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGV
AASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQK
PLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF
RSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAP
GVRVSGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGL
KFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLI
INPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRD
NGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPV
QVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVH
VCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMN
IAPRLYTERSG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6a5o Structural basis of the nucleosome transition during RNA polymerase II passage.
Resolution9.9 Å
Binding residue
(original residue number in PDB)		R490 E522 Q776 K987 H1097 R1124
Binding residue
(residue number reindexed from 1)		R458 E490 Q725 K926 H1036 R1063
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a5o, PDBe:6a5o, PDBj:6a5o
PDBsum6a5o
PubMed30287617
UniProtC4QZQ7

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