Structure of PDB 6a5l Chain B Binding Site BS01

Receptor Information
>6a5l Chain B (length=1161) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRN
LTYSSPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYK
MKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIR
SALEKGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALG
VVPDGEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSA
ALGIRREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCA
LERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETD
RDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYS
STLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNL
SLLSGISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGI
HRDPSMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFI
VEDDESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEE
EETIMIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGV
AASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQK
PLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF
RSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAP
GVRVSGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGL
KFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLI
INPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRD
NGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPV
QVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVH
VCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMN
IAPRLYTERSG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6a5l Structural basis of the nucleosome transition during RNA polymerase II passage.
Resolution5.6 Å
Binding residue
(original residue number in PDB)		R490 P521 R884 K987
Binding residue
(residue number reindexed from 1)		R458 P489 R833 K926
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a5l, PDBe:6a5l, PDBj:6a5l
PDBsum6a5l
PubMed30287617
UniProtC4QZQ7

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