Structure of PDB 6a47 Chain B Binding Site BS01

Receptor Information
>6a47 Chain B (length=217) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLVLP
RVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGF
LSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGL
DRAHSGRKSYSLASLFHRYFQAEPSSAEGDVHTLLLIFLHRAPELLAWAD
EQARSWAHIEPMYVPPD
Ligand information
Receptor-Ligand Complex Structure
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PDB6a47 Structural insights into the duplex DNA processing of TREX2
Resolution1.9 Å
Binding residue
(original residue number in PDB)		E16 A17 G19 L20 P21 N22 M23 D24 K73 I77 H117 N118 Y122 R152 R156 R167 S169 Y170 S171 L172
Binding residue
(residue number reindexed from 1)		E12 A13 G15 L16 P17 N18 M19 D20 K69 I73 H113 N114 Y118 R148 R152 R157 S159 Y160 S161 L162
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6a47, PDBe:6a47, PDBj:6a47
PDBsum6a47
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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