Structure of PDB 5zki Chain B Binding Site BS01

Receptor Information
>5zki Chain B (length=304) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGD
ADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAE
TFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRG
DGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAI
GFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQE
FTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKA
KEQS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zki A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
Resolution2.321 Å
Binding residue
(original residue number in PDB)		R109 S137 R138 G139 A140 A144 G145 F168 N171 S172 N176 L311 R314
Binding residue
(residue number reindexed from 1)		R53 S81 R82 G83 A84 A88 G89 F112 N115 S116 N120 L255 R258
Binding affinityPDBbind-CN: Kd=1.32uM
Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C56 A84 N106 N115 E123
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5zki, PDBe:5zki, PDBj:5zki
PDBsum5zki
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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