Structure of PDB 5zk7 Chain B Binding Site BS01

Receptor Information
>5zk7 Chain B (length=175) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHYIKHPLQNRWALWFFKNDWQANLRLISKFDTVEDFWALYNHIQLSSNL
MPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLL
CLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKE
RLGLPPKIVIGYQSHADTAKNRFVV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zk7 Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		H37 P38 L39 Q40 V69 W73 N77 E132 G139 R186
Binding residue
(residue number reindexed from 1)		H6 P7 L8 Q9 V34 W38 N42 E97 G104 R151
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zk7, PDBe:5zk7, PDBj:5zk7
PDBsum5zk7
PubMed30881679
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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