Structure of PDB 5zi5 Chain B Binding Site BS01

Receptor Information
>5zi5 Chain B (length=850) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKVKKLSDYKSLDYFVIHVDLQIDLSKKPVESKARLTVVPNLNVDSHSND
LVLDGENMTLVSLQMNDNLLKENEYELTKDSLIIKNIPQNTPFTIEMTSL
LGENTDLFGLYETEGVALVKAESEGLRRVFYLPDRPDNLATYKTTIIANQ
EDYPVLLSNGVLIEKKELPLGLHSVTWLDDVPKPSYLFALVAGNLQRSVT
YYQTKSGRELPIEFYVPPSATSKCDFAKEVLKEAMAWDERTFNLECALRQ
HMVAGVDKYASGASEPTGLNLFNTENLFASPETKTDLGILRVLEVVAHEF
FHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELFGTDLIRLLDGKNLD
ERAPRQSAYTAVRSLYTAAAYEKSADIFRMMMLFIGKEPFIEAVAKFFKD
NDGGAVTLEDFIESISNSSGKDLRSFLSWFTESGIPELIVTDELNPDTKQ
YFLKIKTVNGRNRPIPILMGLLDSSGAEIVADKLLIVDQEEIEFQFENIQ
TRPIPSLLRSFSAPVHMKYEYSYQDLLLLMQFDTNLYNRCEAAKQLISAL
INDFCIGKKIELSPQFFAVYKALLSDNSLNEWMLAELITLPSLEELIENQ
DKPDFEKLNEGRQLIQNALANELKTDFYNLLFRIQISGDDDKQKLKGFDL
KQAGLRRLKSVCFSYLLNVDFEKTKEKLILQFEDALGKNMTETALALSML
CEINCEEADVALEDYYHYWKNDPGAVNNWFSIQALAHSPDVIERVKKLMR
HGDFDLSNPNKVYALLGSFIKNPFGFHSVTGEGYQLVADAIFDLDKINPT
LAANLTEKFTYWDKYDVNRQAMMISTLKIIYSNATSSDVRTMAKKGLDKV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5zi5 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zi5 Discovery, Structural and Biochemical Studies of a rare Glu/Asp Specific M1 Class Aminopeptidase from Legionella pneumophila
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H310 H314 E333
Binding residue
(residue number reindexed from 1)		H298 H302 E321
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5zi5, PDBe:5zi5, PDBj:5zi5
PDBsum5zi5
PubMed30172821
UniProtQ5ZVE3

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