Structure of PDB 5zcl Chain B Binding Site BS01

Receptor Information

>5zcl Chain B (length=307) Species: 39947 (Oryza sativa Japonica Group)

PVWGCASTRGRSAEMEDASAAVPRFADVPVRLLASRRDLDALGLDADALR
LPAHLFGVFDGHGGAEVANYCRERIHVVLSAALARLGKNLMGEVDMKEHW
DDVFTKCFQRVDDEVSGRVTRVVNGGGEVRSEPVTAENVGSTAVVALVCS
SHVVVANCGDSRIVLCRGKEPVALSIDHKPDRKDERARIEAQGGKVIQWN
GYRVSGLLAMSRSIGDRYLKPFVIPKPEVMVVPRAKDDDCLILASDGLWD
VVSNEEACKVARRQILLWHKNNSTDPAAQAAADYLMRLALKKGSEDNITV
IVVDLKP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5zcl Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zcl Comprehensive survey of the VxG Phi L motif of PP2Cs from Oryza sativa reveals the critical role of the fourth position in regulation of ABA responsiveness.
• Resolution: 2.661 Å
• Binding residue (original residue number in PDB): D118 D306 D368
• Binding residue (residue number reindexed from 1): D60 D246 D296
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Gene Ontology

Molecular Function

• GO:0004722 protein serine/threonine phosphatase activity
• GO:0043169 cation binding

Biological Process

• GO:0006470 protein dephosphorylation

External links

• PDB: RCSB:5zcl, PDBe:5zcl, PDBj:5zcl
• PDBsum: 5zcl
• PubMed: 31541388
• UniProt: Q6L5H6|P2C50_ORYSJ Protein phosphatase 2C 50 (Gene Name=PP2C50)