Structure of PDB 5ywv Chain B Binding Site BS01

Receptor Information
>5ywv Chain B (length=224) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPP
PVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLA
ILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDS
IAALKALEQASSSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQW
KPQALLQWVDEHARPFSTVKPMYG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ywv Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E20 A21 G23 L24 P25 A81 I84 H124 N125 R128 Y129 I156 S176 Y177 S178 L179 H195
Binding residue
(residue number reindexed from 1)		E15 A16 G18 L19 P20 A76 I79 H119 N120 R123 Y124 I151 S166 Y167 S168 L169 H185
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywv, PDBe:5ywv, PDBj:5ywv
PDBsum5ywv
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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