Structure of PDB 5yvj Chain B Binding Site BS01

Receptor Information
>5yvj Chain B (length=589) Species: 11070 (dengue virus type 4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSEGVYRIMQRGLFGKTQVGVGIHMEGVFHTMWHVTRGSVICHETGRLEP
SWADVRNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLFK
TLGAVTLDFKPGTAGSPIINKKGKVIGLYGNGVSAITQAERIGEPDYEVD
EDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAA
EMEEALRGLPIRYQTPAVKSEHTGREIVDLMCHATFTTRLLSSTRVPNYN
LIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTATPPGSIDPFPQSN
SPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSG
KKVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCL
KPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPL
KNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQ
RKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEV
EIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGRK
Ligand information
>5yvj Chain C (length=15) Species: 11070 (dengue virus type 4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADLSLEKAANVQWDE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yvj Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
Resolution2.508 Å
Binding residue
(original residue number in PDB)		S19 E20 G21 V22 Y23 R24 M26 R28 F46 T53 V57 C59 D94 Q96 H108 N141 K142
Binding residue
(residue number reindexed from 1)		S2 E3 G4 V5 Y6 R7 M9 R11 F29 T36 V40 C42 D77 Q79 H91 N120 K121
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5yvj, PDBe:5yvj, PDBj:5yvj
PDBsum5yvj
PubMed
UniProtF8TEL4

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