Structure of PDB 5yvg Chain B Binding Site BS01

Receptor Information
>5yvg Chain B (length=764) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLQQILQLLKESQSPDTTIQRTVQQKLEQLNLIFVLTKLKSEDEPTRSLS
GLILKNNVKAHFGVTDFIKSECLNNIGDSSPLIRATVGILITTIAWPDLL
PKLCSLLDCEGAFGALQKICEDSAEILNIMIPKFLQFFPKIRSHAVACVN
QFILHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVLPHMHNIVEYML
QRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSD
IDIILSDWNLRKCSAAALDVLANVLPHILPLLKELLFHHEWVVKESGILV
LGAIAMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQP
PDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYIL
DTLVFAFSKYQHKNLLILYDAIGTLADSVLNKPEYIQMLMPPLIQKWNML
KDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLN
NAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCM
QDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCN
NATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIG
RLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPS
GVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQF
PLPLKERLAAFYGV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yvg Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Resolution4.05 Å
Binding residue
(original residue number in PDB)		K377 E498 S502 I540 D543
Binding residue
(residue number reindexed from 1)		K262 E375 S379 I417 D420
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:5yvg, PDBe:5yvg, PDBj:5yvg
PDBsum5yvg
PubMed29677513
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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