Structure of PDB 5ypg Chain B Binding Site BS01

Receptor Information
>5ypg Chain B (length=51) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEEEDVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPS
P
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5ypg Chain B Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ypg Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.
Resolution2.199 Å
Binding residue
(original residue number in PDB)		C18 C21 H36 H39
Binding residue
(residue number reindexed from 1)		C22 C25 H40 H43
Annotation score1
Enzymatic activity
Enzyme Commision number ?
3.6.4.10: non-chaperonin molecular chaperone ATPase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ypg, PDBe:5ypg, PDBj:5ypg
PDBsum5ypg
PubMed30120248
UniProtP11021|BIP_HUMAN Endoplasmic reticulum chaperone BiP (Gene Name=HSPA5);
Q13501|SQSTM_HUMAN Sequestosome-1 (Gene Name=SQSTM1)

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