Structure of PDB 5y58 Chain B Binding Site BS01

Receptor Information
>5y58 Chain B (length=568) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLA
NCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSHDSMIQ
CLLVVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRI
ILIDCGSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELR
LGADILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDS
QKKERYVGVKSIIEYEIHNEGGSSYIPVTISKDSVTKAYRYGADYVVLPS
VLVDQTVYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLM
AFSALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFV
KSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFV
DSMDTDELPEIPLGNYYQPIGEVTTDTTLPLPSLNKDQEENKKDPLRIPT
VFVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTK
LVEVLGIKKVKRGEQHSR
Ligand information
>5y58 Chain X (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggacuuauagauggcuaaaaucugagucca
<<<<<<..<<<<.......>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5y58 Structural Insights into Yeast Telomerase Recruitment to Telomeres
Resolution2.8 Å
Binding residue
(original residue number in PDB)		K39 R41 K42 T43 S204 K251 L256 N257 R258 S278 R318 Y323 V531 Q535
Binding residue
(residue number reindexed from 1)		K38 R40 K41 T42 S187 K234 L239 N240 R241 S261 R290 Y295 V503 Q507
Binding affinityPDBbind-CN: Kd=75nM
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042162 telomeric DNA binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0007535 donor selection
GO:0031509 subtelomeric heterochromatin formation
GO:0034502 protein localization to chromosome
GO:0097695 establishment of protein-containing complex localization to telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043564 Ku70:Ku80 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5y58, PDBe:5y58, PDBj:5y58
PDBsum5y58
PubMed29290466
UniProtQ04437|KU80_YEAST ATP-dependent DNA helicase II subunit 2 (Gene Name=YKU80)

[Back to BioLiP]